Inverse benefits due to drug marketing undermine patient safety and public health | Science Blog
GALVESTON, TX — Drugs that pharmaceutical companies market most aggressively to physicians and patients tend to offer less benefit and more harm to most patients — a phenomenon described as the “inverse benefit law” in a paper from the University of Texas Medical Branch at Galveston.
Published online Thursday, Jan. 13 in the American Journal of Public Health, the article explores recent withdrawals of blockbuster drugs due to safety concerns and finds a clear pattern of physician-focused marketing tactics that ultimately exposed patients to a worsening benefit-to-harm ratio. Potential patient safety and public health implications include unnecessary exposure to adverse side effects, high medical costs and competition for scarce resources.
“This is not a random occurrence, but rather a repeating, planned scenario in which drugs, discovered with good science for a specific set of patients, are marketed to a larger population as necessary, beneficial and safer than other alternatives,” said co-author Dr. Howard Brody, a professor and director of the Institute for the Medical Humanities at UTMB Health. “Marketers are just doing their jobs. However, the reality is that for most new drugs, safety and efficacy are scientifically proven for only a small subset of patients. It’s time for physicians to take a stand and not prescribe them so readily.”
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ABOUT UTMB HEALTH
Established in 1891, Texas’ first academic health center comprises four health sciences schools, three institutes for advanced study, a research enterprise that includes one of only two national laboratories dedicated to the safe study of infectious threats to human health, and a health system offering a full range of primary and specialized medical services throughout Galveston County and the Texas Gulf Coast region. UTMB is a component of the University of Texas System.
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